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Dr. Lakshay Malhotra

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Assistant Professor Department of Biochemistry lakshay@svc.ac.in


Educational Qualifications

  • Ph.D. Department of Biophysics, All India Institute of Medical Sciences, AIIMS, New Delhi
  • M.Sc. (Medical Biotechnology): All India Institute of Medical Sciences, AIIMS, New Delhi (2017-2019)
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Areas of Specialization

  • p53 Biology, Drug designing, Protein engineering, Biochemical and Biophysical techniques, Cell and Molecular Biology, Bioinformatics and Computational Biology, RDT.
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Administrative roles/ responsibilities

Courses Taught

  • Immunobiology, Enzymes, Immunology
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1. Malhotra L, Sharma S, Hariprasad G, Dhingra R, Mishra V, Sharma RS, et al. Mechanism of apoptosis activation by Curcumin rescued mutant p53Y220C in human pancreatic cancer. Biochim Biophys Acta Mol Cell Res. 2022 Dec;1869(12):119343.


2. Malhotra L, Goyal HKV, Jhuria S, Dev K, Kumar S, Kumar M, et al. Curcumin rescue p53Y220C in BxPC-3 pancreatic adenocarcinomas cell line: Evidence-based on computational, biophysical, and in vivo studies. Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129807.


3. Malhotra L, Singh A, Kaur P, Ethayathulla AS. Comprehensive omics studies of p53 mutants in human cancer. Brief Funct Genomics. 2023 Apr 13;22(2):97–108.


4. Malhotra L, Singh A, Kaur P, Ethayathulla AS. Phenotypical mapping of TP53 unique missense mutations spectrum in human cancers [Internet]. bioRxiv; 2023 [cited 2023 May 11]. p. 2023.02.06.527255. Available from: https://www.biorxiv.org/content/10.1101/2023.02.06.527255v1


5. Sharma S, Malhotra L, Mukherjee P, Kaur N, Krishanlata T, Srikanth CV, et al. Putative interactions between transthyretin and endosulfan II and its relevance in breast cancer. Int J Biol Macromol. 2023 Apr 30;235:123670.


6. Singh M, Malhotra L, Haque MA, Kumar M, Tikhomirov A, Litvinova V, et al. Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B. Biochimie. 2021 Mar;182:152–65.


7. Sharma S, Malhotra L, Yadav P, Mishra V, Sharma RS, Abdul Samath E. Genistein: A novel inhibitor of IL-6/IL-6R interface of the Interleukin-6–mediated STAT3 dependent pathway of carcinogenesis. Journal of Molecular Structure. 2022 Jun 15;1258:132668.


8. Chauhan R, Gupta A, Malhotra L, Bhat AA, Pandita RK, Masoodi T, et al. Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression. Journal of Translational Medicine. 2023 Apr 28;21(1):286.


  • Award