image description
  1. home
  2. Faculty

Dr. Manoj Thakur

image description
Assistant Professor Department of Botany manojthakur@svc.ac.in


Educational Qualifications

  • Ph.D.- Department of Biochemistry, Indian Institute of Science, Bengaluru.
  • M.Sc. (Life sciences) – School of Life Sciences, JNU, New Delhi
    •

Areas of Specialization

  • DNA repair and recombination
    •

Administrative roles/ responsibilities

  • Member of the ICT Committee 2023-2025
  • Member of the Debating Society 2023-2025
  • Member of the Prospectus Designing Committee 2023
  • Member of the Department disciplinary Committee
    •

Courses Taught

  • Genetics and Plant Breeding, Molecular Biology, Microbiology and Plant-Microbe Interaction, Plant Diversity and Evolution, Analytical Techniques in Plant Sciences, Inheritance in Biology, Economic Botany and Biotechnology
    •

Thakur M*, Muniyappa K. (2023) Global genome and transcription-coupled nucleotide excision repair pathway in prokaryotes. J Biosci., 48, 56. *Corresponding author


Somashekara SC, Dhyani KM, Thakur M, Muniyappa K. SUMOylation of yeast Pso2 enhances its translocation and accumulation in the mitochondria and suppresses methyl methanesulfonate-induced mitochondrial DNA damage. Mol Microbiol. 2023 Aug 30. doi: 10.1111/mmi.15145


Thakur M*, and Muniyappa K (2023) Macrophage activation highlight an important role for NER proteins in the survival, latency and multiplication of Mycobacterium tuberculosis. Tuberculosis, 138, 102284. *Corresponding author


Thakur M*, Parulekar RS, Barale SS, Sonawane KD, and Muniyappa K*. (2022) Interrogating the substrate specificity landscape of UvrC reveals novel insights into its non-canonical function. Biophys J. 121(16):3103-3125. *Co-corresponding authors


Thakur, M., Mohan, D., Singh. A. K., Agarwal, A., Balasubramanian, G., and Muniyappa, K. (2021) Novel insights into ATP-Stimulated Cleavage of branched DNA and RNA Substrates through Structure-Guided Studies of the Holliday Junction Resolvase RuvX. J. Mol. Biol., 433(13):167014.


Thakur, M., Ankit Agarwal and Muniyappa, K. (2021) The intrinsic ATPase activity of Mycobacterium tuberculosis UvrC is crucial for its damage-specific DNA incision function. The FEBS Journal, 288 (4), 1179–1200.


Thakur, M., and Muniyappa, K. (2020) Deciphering the essentiality and function of SxSx motif in Mycobacterium tuberculosis UvrB. Biochimie 170, 94-105.


Thakur, M., Badugu, S., and Muniyappa, K. (2020) UvrA and UvrC subunits of the Mycobacterium tuberculosis UvrABC excinuclease interact independently of UvrB and DNA. FEBS Lett. 594(5), 851-863.


Thakur, M., Kumar, M. B. J, and Muniyappa, K. (2016) Mycobacterium tuberculosis UvrB is a robust DNA-stimulated ATPase that also possesses structure-specific ATP-dependent DNA helicase activity. Biochemistry, 55 (41), 5865–5883.


Thakur, M., and Muniyappa, K. (2019) Nucleotide Excision Repair Pathway in Mycobacteria. in Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions (Hasnain, S. E., Ehtesham, N. Z., and Grover, S. eds.), Springer Singapore, Singapore. pp 275-300


  • Award

Innovative Teaching