(University of Delhi)
Benito Juarez Road, New Delhi - 110021
(Phone No. - 011-2411 2196 : Email - principal@svc.ac.in)
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Sri Venkateswara College (University of Delhi) Benito Juarez Road, New Delhi - 110021 (Phone No. - 011-2411 2196 : Email - principal@svc.ac.in) |
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| Print Date : 02-08-2025 | ||||||||
| 1. Personal Profile | ||||||
| Title: Dr. First Name: LAKSHAY Last Name: MALHOTRA |
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| Designation: ASSISTANT PROFESSOR Mobile No. ---------- | ||||||
| Phone No. (Office) ---------- Phone No. (Residence): ---------- | ||||||
| Email: lakshayaiims@gmail.com Webpage: ---------- | ||||||
| Facebook: ---------- Twitter: ---------- | ||||||
| LinkedIn: ---------- Instagram: ---------- | ||||||
| Youtube: ---------- Research Gate Link: https://www.researchgate.net/profile/Lakshay-Malhotra-2?ev=hdr_xprf | ||||||
| Google Scholar Link: https://scholar.google.com/citations?user=ALdJVHYAAAAJ&hl=en&oi=sra | ||||||
| Address: ---------- | ||||||
| 2. Educational Qualifications | ||
| Degree/ Certification | Institution | Year |
| B.Sc (H) Biochemistry | Sri Venkateswara College, University of Delhi, India | 2017 |
| M.Sc. Medical Biotechnology | All India Institute of Medical Sciences (AIIMS), New Delhi | 2019 |
| Ph.D. | All India Institute of Medical Sciences (AIIMS), New Delhi | 2023 |
| 3. Career Profile & Administrative Assignments | ||||
| Category | Role/ Designation | Department/ Committee | Date From - To | Remarks |
|---|---|---|---|---|
| 4. Other Profiles |
| Other Profile Name/ Description |
|---|
| AWARDS AND DISTINCTIONS 1. Dr. S.V. Talekar Medal-2023 (Gold Medal) for Best Postgraduate (Ph.D.) from the Department of Biophysics, All India Institute of Medical Sciences (AIIMS), New Delhi 2. DBT - Senior Research Fellowship (2021-2023) 3. DBT - Junior Research Fellowship (2019-2021) 4. CSIR JRF and LS (July 2018) 5. CSIR JRF and LS (Jan 2018) |
| 5. Research Guidance | ||||
| Year | Guide For | Title of the Dissertation/ Thesis | Scholar Name | Status |
|---|---|---|---|---|
| 6. Research Projects | |||||
| Year | Title of Project | Sponsorship Agency | Duration | Amount Sanctioned | Date of Sanction |
|---|---|---|---|---|---|
| 7. Publications | |||||
| Category | Publication Name | Title | Name of Author | Reference Link/ DOI Link |
Publication (Month-Year) |
|---|---|---|---|---|---|
| JOURNAL PAPER (International) |
Unraveling the unique amyloid-like aggregation behavior of the tumor suppressor p53 mutants in human cancers | International Journal of Biological Macromolecules | Nisha Manav, Pratibha Sharma, Sankat Mochan, Lakshay Malhotra (First Author, Corresponding Author) |
https://www.sciencedirect.com/science/article/abs/pii/S0141813025044356 | May 2025 |
| JOURNAL PAPER (International) |
Biophysical and molecular characterization of HuR inhibitors, CMLD-2 and Dihydrotanshinone I (DHTS), in Triple Negative Breast Cancer (TNBC) | Internation Journal of Biological Macromolecules | Arundhathi J.R. Dev, Lakshay Malhotra, Akanksha Kashyap, Sheikh Mohammad Umar, Meetu Rathee, Swarnava Samanta, Rahul Kharkwal, Debarka Sengupta, Chandra Prakash Prasad (Corresponding Author) |
https://www.sciencedirect.com/science/article/pii/S0141813025064037 | July 2025 |
| JOURNAL PAPER (International) |
The R337C mutation in the p53 oligomerization domain affects the regulatory domain and its ability to bind response elements: Evidence based on structural and biophysical studies | Archives of Biochemistry and Biophysics | Alankrita Singh, Lakshay Malhotra, Abhay Mishra, Simran Kundral, Pawan Kumar Tiwari, Saroj Kumar, Hariprasad Gururao, Punit Kaur, Abdul Samath Ethayathulla (Joint Author) |
https://www.sciencedirect.com/science/article/abs/pii/S0003986125000943 | March 2025 |
| JOURNAL PAPER (International) |
Phenotypical mapping of TP53 unique missense mutations spectrum in human cancers | Journal of Biomolecular Structure and Dynamics | Lakshay Malhotra, Alankrita Singh, Punit Kaur & Abdul S. Ethayathulla (First Author) |
https://www.tandfonline.com/doi/abs/10.1080/07391102.2024.2435060 | December 2024 |
| JOURNAL PAPER (International) |
Elevated Serum sFlt-1 In Preeclamptic Mothers Activates GRP78 In Placenta | African Journal of Biomedical Research | Sankat Mochan, Chandan Kumar, Rinke Choudhary , Vishnu Swarup, Lakshay Malhotra, Mohd Anas Khan, Pallavi Arora, Renu Dhingra (Joint Author) |
https://africanjournalofbiomedicalresearch.com/index.php/AJBR/article/view/6646 | November 2024 |
| JOURNAL PAPER (International) |
Bergenin inhibits growth of human cervical cancer cells by decreasing Galectin-3 and MMP-9 expression | Scientific Reports | Ravi Chauhan, Lakshay Malhotra, Ashna Gupta, Gunjan Dagar, Mohini Mendiratta, Tariq Masoodi, Sheema Hashem, Sara Al Marzooqi, Dayasagar Das, Shahab Uddin, Abdul Samath Ethayathulla, et al. (Joint Author) |
https://www.nature.com/articles/s41598-024-64781-3 | July 2024 |
| JOURNAL PAPER (International) |
Comprehensive amino acid composition analysis of seed storage proteins of cereals and legumes: identification and understanding of intrinsically disordered and allergenic peptides | Journal of Biomolecular Structure and Dynamics | Pratibha Sharma, Lakshay Malhotra & Rajinder K. Dhamija (Joint Author) |
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2300126 | January 2024 |
| JOURNAL PAPER (International) |
Flavonoids as potential reactivators of structural mutation p53Y220C by computational and cell-based studies | Journal of Biomolecular Structure and Dynamics | Lakshay Malhotra, Punit Kaur & Abdul Samath Ethayathulla (First Author) |
https://www.tandfonline.com/doi/abs/10.1080/07391102.2023.2252071 | August 2023 |
| JOURNAL PAPER (International) |
Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression | Journal of Translational Medicine | Ravi Chauhan, Ashna Gupta, Lakshay Malhotra, Ajaz A. Bhat, Raj K. Pandita, Tariq Masoodi, et al. (Joint Author) |
https://link.springer.com/article/10.1186/s12967-023-04126-2 | April 2023 |
| JOURNAL PAPER (International) |
Putative interactions between transthyretin and endosulfan II and its relevance in breast cancer | International Journal of Biological Macromolecules | Saurabh Sharma, Lakshay Malhotra, Paromita Mukherjee, Navneet Kaur, Thammineni Krishanlata, Chittur V. Srikanth, Vandana Mishra, Basu Dev Banerjee, Abdul Samath Ethayathulla, Radhey Shyam Sharma (Joint Author) |
https://www.sciencedirect.com/science/article/abs/pii/S0141813023005639 | February 2023 |
| JOURNAL PAPER (International) |
Mechanism of apoptosis activation by Curcumin rescued mutant p53Y220C in human pancreatic cancer | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | Lakshay Malhotra, Saurabh Sharma, Gururao Hariprasad, Renu Dhingra, Vandana Mishra, Radhey S. Sharma, Punit Kaur, Abdul S. Ethayathulla (First Author) |
https://www.sciencedirect.com/science/article/pii/S0167488922001355 | August 2022 |
| JOURNAL PAPER (International) |
Comprehensive omics studies of p53 mutants in human cancer | Briefings in Functional Genomics | Lakshay Malhotra , Alankrita Singh , Punit Kaur , Abdul S Ethayathulla (First Author) |
https://academic.oup.com/bfg/article/22/2/97/6637505 | July 2022 |
| JOURNAL PAPER (International) |
Genistein: A novel inhibitor of IL-6/IL-6R interface of the Interleukin-6–mediated STAT3 dependent pathway of carcinogenesis | Journal of Molecular Structure | Saurabh Sharma, Lakshay Malhotra, Prakarsh Yadav, Vandana Mishra, Radhey Shyam Sharma, Ethayathulla Abdul Samath (Joint Author) |
https://www.sciencedirect.com/science/article/abs/pii/S0022286022003416 | February 2021 |
| JOURNAL PAPER (International) |
Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B | Biochimie | Mandeep Singh, Lakshay Malhotra, Md Anzarul Haque, Mukesh Kumar, Alexander Tikhomirov, Valeria Litvinova, Alexander M. Korolev, A.S. Ethayathulla, Uddipan Das, Andrey E. Shchekotikhin, Punit Kaur (Joint Author) |
https://www.sciencedirect.com/science/article/abs/pii/S030090842030345X | January 2021 |
| JOURNAL PAPER (International) |
Curcumin rescue p53Y220C in BxPC-3 pancreatic adenocarcinomas cell line: Evidence-based on computational, biophysical, and in vivo studies | Biochimica et Biophysica Acta (BBA) - General Subjects | Lakshay Malhotra, Harsh K.V. Goyal, Sunita Jhuria, Kapil Dev, Saroj Kumar, Manoj Kumar, Punit Kaur, Abdul S. Ethayathulla (First Author) |
https://www.sciencedirect.com/science/article/pii/S0167488922001355 | December 2020 |
| CONFERENCE PAPER/ PROCEEDINGS (International) |
Exploring the therapeutic potential of USP14 in cervical cancer: mechanisms of oncogenesis and metabolic regulation | Cancer Research | Ravi Chauhan; Lakshay Malhotra; Ashna Gupta; Gunjan Dagar; Harshul Kapoor; Sandeep R. Mathur; Ethayathulla Abdul Samath; Mayank Singh (Joint Author) |
https://aacrjournals.org/cancerres/article/85/8_Supplement_1/5574/757827 | April 2025 |
| CONFERENCE PAPER/ PROCEEDINGS (International) |
Ubiquitin specific peptidase 37 facilitate prostate cancer oncogenesis by regulation replication stress | Cancer Research | Gunjan Dagar; Asha Khuswaha; Lakshay Malhotra; Ashna Gupta; Ajaz Bhat; Ammira S Al-Shabeeb Akil; Atul Batra; Seema Khausal; Mayank Singh (Joint Author) |
https://aacrjournals.org/cancerres/article/85/8_Supplement_1/1429/758089 | April 2025 |
| CONFERENCE PAPER/ PROCEEDINGS (International) |
Bergenin inhibits growth of human cervical cancer cells by decreasing galectin-3 and MMP-9 expression | Cancer Research | Mayank Singh; Ravi Chauhan; Lakshay Malhotra; Ashna Gupta; Gunjan Dagar; Dayasagar Das; Shahab Uddin; Ethayathulla Abdul Samath et al. (Joint Author) |
https://aacrjournals.org/cancerres/article/84/6_Supplement/1830/738042 | March 2024 |
| CONFERENCE PAPER/ PROCEEDINGS (International) |
Unraveling the oncogenic network of USP37 and USP14 in gynecological cancers: Decrypting the molecular landscape of chemoresistance | Cancer Research | Ravi Chauhan; Ashna Gupta; Gunjan Dagar; Lakshay Malhotra; Ekta Rai; Muzafar A Macha; Ajaz A Bhat; Ethayathulla A Samath; Mayank Singh (Joint Author) |
https://aacrjournals.org/cancerres/article/84/6_Supplement/4639/736191 | March 2024 |
| CONFERENCE PAPER/ PROCEEDINGS (International) |
Decoding the interplay of deubiquitinating enzymes (DUBs) in metastasis and chemoresistance of gynaecological cancers | ESMO open | R. Chauhan ∙ A. Gupta∙ G. Dagar∙ L. Malhotra∙ S. De∙ E.A. Samath∙ N. Singh∙ M. Singh (Joint Author) |
https://www.esmoopen.com/article/S2059-7029(24)00325-9/fulltext | March 2024 |
| CONFERENCE PAPER/ PROCEEDINGS (International) |
Ubiquitin Specific Peptidase 37promotes Osteosarcoma oncogenesis by interacting with PCNA and impacting constitutive replication fork movement. | Cancer Research | Ravi Chauhan; Lakshay Malhotra; Ashna Gupta; Ajaz Bhat; Gunjan Dagar; Tariq Masoodi; Muzafar A. Macha; Ethayathulla Abdul Samath et al. (Joint Author) |
https://aacrjournals.org/cancerres/article/83/7_Supplement/335/719458/Abstract-335-Ubiquitin-Specific-Peptidase | April 2023 |
| 8. Books | ||||
| Category | Book Name | Title | Name of Author | ISSN/ ISBN Number |
|---|---|---|---|---|
| 9. Faculty Achievements | |||||
| Year | Category of Achievement | Role | National/ International etc. | Name | Date From-To |
|---|---|---|---|---|---|
| 2023 | FACULTY INDUCTION PROGRAM ATTENDED | PARTICIPANT | National | 4-Week Faculty Induction/Orientation Programme for “Faculty in Universities/Colleges/Institutes of Higher Education” | 23.Apr.2023 - 22.May.2023 |
| 2025 | REFRESHER COURSE ATTENDED | PARTICIPANT | National | Online Refresher Course (Multidisciplinary/Interdisciplinary Course) on the theme “Mental Health & Wellbeing in Higher Education Institutions: A Step Towards Viksit Bharat” | 10.Mar.2025 - 24.Mar.2025 |
| 2025 | FACULTY DEVELOPMENT PROGRAM ATTENDED | PARTICIPANT | National | One-Week Online National Faculty Development Program on "CANCER AWARENESS FOR COMMUNITY ENGAGEMENT @NEP 2020" | 11.Feb.2025 - 18.Feb.2025 |
| Dr. LAKSHAY MALHOTRA |