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Dr. Rangarajan T. M.

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Assistant Professor Department of Chemistry rangarajan93150@gmail.com


Educational Qualifications

  • M.Sc., M.Phil., Ph.D.

Areas of Specialization

  • Organic Chemistry: Research interest- Cross-coupling reactions, Organic Synthesis, MAO inhibitors, Fluorine chemistry

Administrative roles/ responsibilities

  • Member, Departmental Magazine committee, Sports committee.

Courses Taught

  • B. Sc. (H) Chemistry, B. Sc. (Life Sciences) & B. Sc. (H) GE

2023
1. H K. Perumal, J. Lee, S. B. Annes, S. Ramesh, T. M. Rangarajan, B. Mathew, Hoon Kim, “An efficient method to access spiro pseudoindoxyl ketones: evaluation of indoxyl and their Nbenzylated derivatives for inhibition of the activity of monoamine oxidases,” RSC Adv., 2023, 13, 24925- 24935. ISSN: 2046-2069. I.F. – 3.90.


2. A. K. Singh, S. –M. Kim, J. M. Oh, M. A. Abdelgawad, M. M. Ghoneim, T. M. Rangarajan, S. Kumar, S. T. Sudevan, D. Trisciuzzi, O. Nicolotti, H. Kim, B. Mathew, “Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones,” Chemical Biology & Drug Design, 2023, 102, 271– 284. ISSN: 1747-0285. I.F. – 3.00.


3. A. Krishna, S. Kumar, S. T. Sudevan, A. K. Singh, L. K. Pappachen, T. M. Rangarajan, M. A. Abdelgawad, B. Mathew, “A Comprehensive Review of the Docking Studies of Chalcone for the Development of Selective MAO-B Inhibitors,” CNS-Neurological Disorders - Drug Targets, 2023, 22, 000-000. ISSN: 1996-3181. I.F. – 3.00.


4. K. Anusha, M. Megha, Shikha, T. M. Rangarajan*, Sharda Pasricha*, “Langlois’ Reagent: An Efficient Trifluoromethylation Reagent”, SynOpen, 2023, 07, 65-68. ISSN: 2509-9396. IF –2.5.


5. S. Abhay, A. Nishita, Sachidanand, Y. Divya, T. M. Rangarajan*, Sharda Pasricha*, “Solid-support Heterogenized Palladium Nanoparticles: Propitious Vehicles for Sonogashira Cross-Coupling Reaction”, SynOpen, 2023, 07, 43-45. ISSN: 2509-9396. IF –2.5.


6. Sharda Pasricha, T. M. Rangarajan, “A simple and benign route to acetylation of primary aromatic amines: An undergraduate chemistry experiment”, Resonance: Journal of Science Education, 2023, 28, 325-331. ISSN: 0973-712X. IF – NA.


2022
7. T. S. Sachithra, J. M. Oh, M. A. Abdelgawad, M. A. S. Abourehab, T. M. Rangarajan, K. Sunil, I. Ahmad, H. Patel, H. Kim, B. Mathew, “Introduction of benzyloxy pharmacophore into aryl/ heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors”, Scientific Reports, 2022, 12, 22404-22422. ISSN: 2045-2322. IF – 4.996.


8. B. Mathew, V. Ravichandran, S. Raghuraman, T. M. Rangarajan, M. A. Abdelgawad, I. Ahmad, H. M. Patel & Hoon Kim, “Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime- and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors”, Journal of Biomolecular Structure and Dynamics, 2022, DOI: https://doi.org/10.1080/07391102.2022.2146198. ISSN: 1538-0254. IF - 5.235.


9. S. N. Aathira, K. S. Ashutosh, K. Astik, K. Sunil, S. Sukumaran, P. K. Vishal, K. P. Leena, T. M. Rangarajan, H. Kim, M. Bijo, "FDA-Approved Trifluoromethyl Group-Containing Drugs: A Review of 20 Years", Processes, 2022, 10, 2054. ISSN: 2227-9717. IF - 3.352.


10. T. S. Sachithra, T. M. Rangarajan, A. G. Al-Sehemi, S. N. Aathira, P. K. Vishal, Bijo Mathew, “Revealing the role of benzyloxy pharmacophore in the design of a new class of MAO-B inhibitors”, Archiv der Pharmazie, 2022, 335, e2200084. ISSN:1521-4184. IF – 4.613.


11. B. Mathew, H. A. Chonny, D. Sanal, T. M. Rangarajan, N. Marraiki, G. E. S. Batiha, L. Scotti, M. T. Scotti, "Development of 2D, 3D-QSAR and Pharmacophore Modeling of Chalcones for the Inhibition of Monoamine Oxidase B", Combinatorial Chemistry & High Throughput Screening, 2022, 25, 1731 – 1744. ISSN: 1875-5402. IF – 1.714.


12. Jong Min Oh, T. M. Rangarajan*, Reeta Chaudhary, Nicola Gambacorta, Orazio Nicolotti, Sunil Kumar, Bijo Mathew*, Hoon Kim, “Aldoxime- and Hydroxy-Functionalized Chalcones as Highly Potent and Selective Monoamine Oxidase-B Inhibitors”, Journal of Molecular Structure, 2022, 1250, 131817-131829. ISSN: 0022-2860. IF – 3.841.


2021
13. Bijo Mathew, Jong-Min Oh, Ahamed Khames, Mohamed A Abdelgawad, T. M. Rangarajan, Lekshmi R Nathg, Clement Agoni, Mahmoud E. S. Soliman, Githa Elizabeth Mathew, Hoon Kim, “Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and their Protein-Ligand Interactions”, Pharmaceuticals, 2021, 14, 1448-1464. ISSN: 1424-8247.


14. T. M. Rangarajan, Bijo Mathew, Updates on Pyrazolines Derivatives as Promising Scaffold for Neuropsychiatric and Neurodegenerative disorders, Current Topics in Medicinal Chemistry, 2021, 21, 2695-2714. ISSN: 1873-4294.


15. V. P. Koyiparambath, K. P. Rajappan, T. M. Rangarajan, G. A. S. Abdullah, M. Pannipara, V. Bhaskar, A. S. Nair, S. T. Sudevan, S. Kumar, B. Mathew, "Deciphering the detailed structure-activity relationship of coumarins as Monoamine oxidase enzyme inhibitors-An updated review" Chemical Biology & Drug Design, 2021, 98, 655 – 673. ISSN: 1747-0285.


16. A. R. Nisha, G. A. S. Abdullah, D. G. T. Parambi, T. M. Rangarajan, O. Nicolotti, K. Hoon, B. Mathew, "Current Progress in quinazoline derivatives as acetylcholinesterase and monoamine oxidase inhibitors" ChemistrySelect, 2021, 6, 7162-7182. ISSN: 2365-6549.


2020
17. A. Palakkathondi, J. M. Oh, S. Dev, T. M. Rangarajan, S. Kaipakasseri, F. S. Kavully, N. Gambacorta, O. Nicolotti, H. Kim, Bijo Mathew, "(Hetero-)(Arylidene)arylhydrazides as Multitarget-Directed Monoamine Oxidase Inhibitors", ACS Combinatorial Science, 2020, 22, 592-599. ISSN: 2156-8944,


18. J. M. Oh, T. M. Rangarajan*, Reeta, R. P. Singh, Manjula Singh, Raj Pal Singh, A. R. Tondo, N. Gambacorta, O. Nicolotti, Bijo Mathew*, Hoon Kim, “Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors”, Molecules, 2020, 25, 2356-2371. ISSN: 1420-3049.


19. Reeta, T. M. Rangarajan*, Raj Pal Singh, Rishi Pal Singh*, Manjula Singh, “An Easy Access to Oxime ethers by Pd‐Catalyzed C–O Cross‐Coupling of Activated Aryl bromides with Ketoximes and Chalcone oximes”, Chinese Journal of Chemistry, 2020, 38, 830-836. ISSN: 1614-7065.


20. Reeta, T. M. Rangarajan*, Kumar Kaushik, Rishi Pal Singh, Manjula Singh, and Raj Pal Singh, “Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C–O cross-coupling of aldoximes with aryl bromides and bromo-chalcones”, New Journal of Chemistry, 2020, 44, 1326-1336. ISSN: 1369-9261.


2019
21. Reeta, Seung Cheol Baek, Jae Pil Lee, T. M. Rangarajan*, Ayushee, Rishi Pal Singh, Manjula Singh, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Hoon Kim*, Bijo Mathew,* “Ethyl Acetohydroxamate Incorporated Chalcones: Discovery of A Novel Class Of Multimodal Monoamine Oxidase-B Inhibitors Against Alzheimer’s Disease”, CNS Neurological Disorders - Drug Targets, 2019, 18, 643-654. ISSN: 1996-3181.


22. Reeta, V. Rajendran, T. M. Rangarajan*, Ayushee, R. P. Singh*, Manjula Singh, “Synthesis of Novel Chalcones through Palladium-Catalyzed C–O Cross-Coupling Reaction of Bromo-Chalcones with Ethyl Acetohydroxamate and Their Antiplasmodial Evaluation against Plasmodium falcipuram in Vitro”, Bioorganic Chemistry, 2019, 86, 631-640. ISSN: 0045-2068.


2018
23. K. Devi, V. Rajendran, Ayushee, T. M. Rangarajan,* R. P. Singh*, P. C. Ghosh, Manjula Singh, “Synthesis and Evaluation of Antiplasmodial Activity of 2,2,2-Trifluoroethoxychalcones and 2-Fluoroethoxy Chalcones against Plasmodium falciparum in Culture”, Molecules, 2018, 23, 1174-1202. ISSN: 1420-3049.


2016
24. Reeta, T. M. Rangarajan,* Ayushee, Rishi Pal Singh, R. P. Singh,* “Palladium-Catalyzed Rapid Methoxylation and Deuteriomethoxylation of Bromo-Chalcones: Uncovering the Catalytic Activity of the Pd/tBuXPhos Catalyst System”, ChemistrySelect, 2016, 1, 6894-6901. ISSN: 2365-6549.


25. T. M. Rangarajan,* Kavita Devi, Akhilesh K. Verma, Rishi Pal Singh and Raj Pal Singh,* “A General and Efficient Pd-Catalyzed Rapid 2-Fluoroethoxylation of Bromo-Chalcones”, Journal of Fluorine Chemistry, 2016, 186, 101-110. ISSN: 0022-1139.


2015
26. T. M. Rangarajan,* Kavita Devi, Ayushee, Ashok K. Prasad, Rishi Pal Singh,* “A General, Mild, and Efficient Palladium-Catalyzed 2,2,2-Trifluoroethoxylation of Activated Aryl Bromides and Bromo-Chalcones: Bromo-Chalcones a New Coupling Partner in Cross-Coupling Reaction”, Tetrahedron, 2015, 71, 8307-8314. ISSN: 0040-4020.


27. T. M. Rangarajan,* Raju Brahma, Ayushee, Ashok K. Prasad, Akhilesh K. Verma and Rishi Pal Singh, “Mild and Efficient Palladium/BrettPhos-Catalyzed Methoxylation and Deuteriomethoxylation of Activated Aryl Bromides”, Tetrahedron Letters, 2015, 56, 2234-2237. ISSN: 0040-4039,


2014
28. T. M. Rangarajan, Rajendra Singh, Raju Brahma, Kavita Devi, Rishi Pal Singh, R. P. Singh, and Ashok K. Prasad, “BrettPhos Ligand Supported Palladium-Catalyzed C‒O Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides”, Chemistry - A European Journal, 2014, 20, 14218-14225. ISSN: 1521-3765.


2011
29. T. M. Rangarajan, S. Sathyamoorthi, D. Velayutham, M. Noel, R. P. Singh and Raju Brahma, “Products Formed at Intermediate Stages of Electrochemical Perfluorination of Propionyl and n-Butyryl Chlorides. Further Evidence in Support of NiF3 Mediated Free Radical Pathway”, Journal of Fluorine Chemistry, 2011, 132, 107-113. ISSN: 0022-1139.


30. T. M. Rangarajan, D. Velayutham and M. Noel, “Anodic oxidation of alkane carboxylates and perfluoroalkane carboxylates at platinum and graphite anodes: Product selectivity and mechanistic aspects”, IONICS, 2011, 17, 827-833. ISSN: 1862-0760.


PATENTS

“Composition for preventing or treating neurodegenerative disease comprising ethyl acetohydroxamate incorporated chalcones as an active ingredient”, Hoon Kim, Seung Cheol Baek, Jae Phil Lee, Bijo Mathew, T. M. Rangarajan, Reeta, Provisional Patent No. 10-2020-0054743, 2020, Korean Intellectual Property Office Korea, Republic of Korea.


“A fluorinating mixture and applications thereof”, Raj P. Singh, K. Kaushik, C. Prakash, Rajendra Singh, Chitra Rajagopal, Rajiv Narang, T. M. Rangarajan, Y. L. N. Murthy, Govindh, Boddeti Rao, Nethinti Sundara, Indian Pat. Appl. (2020), IN 201811030226 A 20200214.


“Preparation of chalcone derivatives and uses thereof for the treatment of malaria”, Raj P. Singh, K. Devi, T. M. Rangarajan, Brijesh Rathi, R. Vinoth; P. Ghosh Chandra, R. P. Singh, Indian Pat. Appl. (2019), IN 201711041295 A 20190524.


“A process for the preparation of Aryl alkyl ethers derivatives” T. M. Rangarajan, Raju Brahma, Rajendra Singh, R. P. Singh, Raj P. Singh, Indian Pat. Appl. (2017), IN 2015DE02406 A 20170210.


“A process for the preparation of arylalkyl ether derivatives”, T. M. Rangarajan, Rajendra Singh, R. Brahma, K. Devi, Raj P. Singh, Indian Pat. Appl. (2015), IN 2013DE03555 A 20150612.


REVIEWER

1. Scientific Reports (2) - (Springer Nature Limited)


2. Letters in Organic Chemistry (1) - (Bentham Science)


3. RSC-Advances (4) - (RSC)


4. International Journal of Biochemistry Research & Review (1)


5. Journal of Organic Chemistry (1) - (ACS)


6. Organic Letters (1) - (ACS)


7. Indian Journal of Chemistry-Sec-B (1) - (CSIR–NIScPR)


8. Journal of Heterocyclic Chemistry (1) – (Wiley)


9. Journal of Fluorescence (1) – (Springer)


10. Computational Toxicology (1) – (Elsevier)


  • Award